View source for Vitamin-K-epoxide reductase (warfarin-sensitive)

{{enzyme
| Name = vitamin-K-epoxide reductase (warfarin-sensitive)
| EC_number = 1.17.4.4
| CAS_number = 55963-40-1
| IUBMB_EC_number = 1/17/4/4
| GO_code = 0047057
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''vitamin-K-epoxide reductase (warfarin-sensitive)''' ({{EC number|1.17.4.4}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol <math>\rightleftharpoons</math> 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[2-methyl-3-phytyl-1,4-naphthoquinone]] and [[oxidized dithiothreitol]], whereas its two [[product (chemistry)|products]] are [[2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone]] and [[1,4-dithiothreitol]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH or CH2 groups of donor with a disulfide as acceptor.  The [[List of enzymes|systematic name]] of this enzyme class is '''2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase'''. This enzyme participates in [[biosynthesis of steroids]].  At least one compound, [[Warfarin]] is known to [[enzyme inhibitor|inhibit this enzyme]].

== References ==
{{reflist|1}}
* {{cite journal | vauthors = Lee JJ, Fasco MJ | date = 1984 | title = Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction with a common disulfide | journal = Biochemistry  | volume = 23 | pages = 2246–52  | pmid = 6733086 | doi = 10.1021/bi00305a024 | issue = 10 }}
* {{cite journal | vauthors = Mukharji I, Silverman RB | date = 1985 | title = Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone | journal = Proc. Natl. Acad. Sci. U.S.A.  | volume = 82 | pages = 2713–7  | pmid = 3857611 | doi = 10.1073/pnas.82.9.2713 | issue = 9 | pmc = 397635 | doi-access = free }}
* {{cite journal | vauthors = Whitlon DS, Sadowski JA, Suttie JW | date = 1978 | title = Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition | journal = Biochemistry  | volume = 17 | pages = 1371–7  | pmid = 646989 | doi = 10.1021/bi00601a003 | issue = 8 }}

{{Alcohol oxidoreductases}}
{{Enzymes}}
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[[Category:EC 1.17.4]]
[[Category:Enzymes of unknown structure]]


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